Purpose: Skin is the most important organ of the body and maintains its integrity is critical in good health. Severe skin damage is life-threatening and repairing restores its tissue integrity and delay in it endangers health. According to the importance of wound healing and the fact that not treated wounds may decrease quality of life, many studies have investigated the effect of some natural and chemical substance on the length and quality of wound healing to find out beneficial interventions that rapidly and economically treat it. This review aimed to describe the physiology of cutaneous wound healing and some negative and positive factor with a focus on exercise. Methods: An electronic search without any time limitation was performed on the PubMed, Google scholar and web of science databases to find published articles in English. The keywords were wound healing, exercise, and physiology. According to relation to subject, similarities, and differences 48 articles were selected and reviewed. Results: wound healing is a complicated physiology process that consists of four consecutive overlapping stages. Disruption in each stage disturbs wound healing. Many chemical and herbal compounds are used to speed up wound recovery due to their anti-inflammatory property. Exercise is one of the effective factors in wound healing and many studies evaluated effect of different protocol of exercise on it. The results of studies show that aerobic exercise due to its anti-inflammatory and antioxidative effect is a beneficial method in shortening the length of wound healing, especially in aged, fat, and diabetic individuals. Conclusion: Moderate intensity aerobic exercise as a complementary medicine is a good intervention in the treatment of impaired and chronic wounds.