Document Type : Research Paper

Authors

Department of Physical Education and Sport Sciences, Mohaghegh Ardabili University, Ardabil, Iran

Abstract

Purpose: The aim of this study was to compare the effect of eight weeks of aerobic, resistance and combination training on serum levels of irizin, atherogenic index of plasma (AIP) and some cardiovascular risk factors in inactive overweight men. Methods: In this quasi-experimental study, 32 inactive overweight men participated voluntarily and were randomly divided into 4 groups: aerobic training, resistance training, combination training and control. Serum levels of irizin, AIP and lipid profile of subjects were measured before and after eight weeks of exercise. Results: After eight weeks of exercise intervention, irizin levels increased significantly in all three experimental groups (P <0.05). Also, AIP decreased significantly in all three training groups (P <0.05). On the other hand, in examining the differences between groups, a significant difference was observed between the groups in AIP and irisin (P <0.05). Conclusion: The results of the present study showed that eight weeks of exercise training can possibly cause favorable changes in plasma irisin and biochemical parameters of the blood in overweight people. Also, combined training seems to have more favorable effects than other training methods.

Keywords

Main Subjects

Abasi, Salar, & Nikseresht, Mahmoud. (2018). Comparison of serum apelin levels and maximal oxygen consumption in active and inactive obese men. KAUMS Journal (FEYZ), 22(4), 387-393. 
Abbasi Soltani, Hamed, & Zehsaz, Farzad. (2018). The Effect of PPARα Gene Polymorphism on Some Athletic Performances of Non-Athletic 10-12 Year-Old Boys of Marand. Journal of Arak University of Medical Sciences, 21(5), 88-97. 
Acar, Hakan, & Eler, Nebahat. (2019). The Relationship between body composition and jumping performance of volleyball players. Journal of Education and Training Studies, 7(3), 192-196. 
Adrien, Ngayimbesha, & Felix, Nzisabira. (2017). EFFECT OF 8 WEEKS OF AEROBIC EXERCISE TRAINING COMBINED TO DIET CONTROL ON LIPID PROFILE IN OBESE PERSON. International Journal of
Sports Sciences & Fitness, 7(2). 
Alm, Petter S, Krook, Anna, & de Castro Barbosa, Thais. (2016). Maternal obesity legacy: exercise it away! Diabetologia, 59, 5-8. 
Ardabili, Mohaghegh. (2017). The effect of a 12 week plyometric and soccer training on the cardiac structure and function among the 13-15 years old
boys. Feyz, Journal of Kashan University of Medical Sciences, 21(1), 94101. 
Aydin, Suleyman, Aydin, Suna, Kuloglu, Tuncay, Yilmaz, Musa, Kalayci, Mehmet, Sahin, İbrahim, & Cicek, Demet. (2013). Alterations of irisin concentrations in saliva and serum of obese and normal-weight subjects, before and after 45 min of a Turkish bath or running. Peptides, 50, 13-18. 
Azarbayjani, Mohammad Ali, Abedi, Bahram, Peeri, Maghsoud, Rasaee, Mohammad Javad, & Stannard, Stephen R. (2014). Effects of combined aerobic and resistant training on lipid profile and glycemic control in sedentary men. Int Med J, 21(2), 132-136. 
Boström, Pontus, Wu, Jun, Jedrychowski, Mark P, Korde, Anisha, Ye, Li, Lo, James C, . . . Long, Jonathan Z. (2012). A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature, 481(7382), 463-468. 
Dobiasova, M. (2006). AIP--atherogenic index of plasma as a significant predictor of cardiovascular risk: from research to practice. Vnitrni lekarstvi, 52(1), 64-71. 
Durstine, J Larry, Grandjean, Peter W, Cox, Christopher A, & Thompson, Paul D. (2002). Lipids, lipoproteins, and exercise. Journal of Cardiopulmonary Rehabilitation and Prevention, 22(6), 385-398. 
Fan, Jiamao, Zhu, Qing, Wu, Zhenhua, Ding, Jiao, Qin, Shuai, Liu, Hui, & Miao, Pengfei. (2020). Protective effects of irisin on hypoxia‐reoxygenation injury in hyperglycemia‐treated cardiomyocytes: Role of AMPK pathway and mitochondrial protection. Journal of Cellular Physiology, 235(2), 1165-1174. 
Foroutan, Y, Pehpoor, N, Tadibi, V, & Danashyar, S. (2019). The Effect of 8 Weeks of Concurrent Training on Serum Leptin Levels, Lipid Profiles and Body Composition of Overweight Inactive Men. The Horizon of Medical Sciences, 25(1), 57-63. 
Gizaw, Mamo, Anandakumar, Pandi, & Debela, Tolessa. (2017). A review on the role of irisin in insulin resistance and type 2 diabetes mellitus. Journal of pharmacopuncture, 20(4), 235. 
Hecksteden, Anne, Wegmann, Melissa, Steffen, Anke, Kraushaar, Jochen, Morsch, Arne, Ruppenthal, Sandra, . . . Meyer, Tim. (2013). Irisin and exercise training in humans–results from a randomized controlled training trial. BMC medicine, 11(1), 1-8. 
Hejazi, Keyvan, Ziaaldini, Mosaferi, Attarzadeh Hosseini, Seyyed Reza, & Fathi, Mehrdad. (2020). The impact of aerobic training intensity on skeletal muscle PGC-1α, interferon regulatory factor 4, and atherogenic index in obese male Wistar rats. Iranian Journal of Veterinary Science and Technology, 12(2), 50-58. 
Hernández-Reyes, Alberto, Cámara-Martos, Fernando, Recio, Guillermo Molina, Molina-Luque, Rafael, Romero-Saldaña, Manuel, & Rojas, Rafael Moreno. (2020). Push notifications from a mobile app to improve the body composition of overweight or obese women: randomized controlled trial. JMIR mHealth and uHealth, 8(2), e13747. 
Huh, Joo Young, Mougios, Vassilis, Kabasakalis, Athanasios, Fatouros, Ioannis, Siopi, Aikaterina, Douroudos, Ioannis I, . . . Mantzoros, Christos S. (2014). Exercise-induced irisin secretion is independent of age or fitness level and increased irisin may directly modulate muscle metabolism through AMPK activation. The Journal of Clinical Endocrinology & Metabolism, 99(11), E2154-E2161. 
Huh, Joo Young, Siopi, Aikaterina, Mougios, Vassilis, Park, Kyung Hee, & Mantzoros, Christos S. (2015). Irisin in response to exercise in humans with and without metabolic syndrome. The Journal of Clinical Endocrinology & Metabolism, 100(3), E453-E457. 
Jafari, Mohsen, Pouryamehr, Elham, Rabbani, Hamideh, & Heydari, Mahboubeh.
(2020). Effect of Eight Weeks High Intensity Interval Training (HIT) on
Adhesive Molecules in Obese Young Women. Journal of Applied Exercise Physiology, 16(31), 145-154. 
Jafari, Mohsen, & Ravasi, Ali Asghar. (2021). Acute and chronic effects of exercise on irisin in healthy adults. Medical Science Journal of Islamic Azad Univesity-Tehran Medical Branch, 31(2), 135-145. 
Javadifar, Kobra, Gaeini, Abbas Ali, Haddadi, Rasool, & Ravasi, Ali Asghar. (2021). Interactive effect of endurance exercise, resistance exercise, and cold weather on irisin changes in diabetic male rats. Journal of Basic Research in Medical Sciences, 8(2), 35-44. 
Karbalamahdi, Afsaneh, Abedi, Bahram, Fatolahi, Hoseyn, & Pazoki, Alireza. (2019a). Effect of aerobic training and C. vulgaris intake on lipid profile
and leptin in obese women. Hormozgan Medical Journal, 23(2), e91436e91436. 
Karbalamahdi, Afsaneh, Abedi, Bahram, Fatolahi, Hoseyn, & Pazoki, Alireza. (2019b). Effect of Aerobic Training and C. vulgaris Intake on Lipid
Profile and Leptin in Obese Women. Hormozgan Medical Journal, 23(2). 
Kim, Hee-jae, So, Byunghun, Choi, Mijung, Kang, Dongheon, & Song, Wook. (2015). Resistance exercise training increases the expression of irisin concomitant with improvement of muscle function in aging mice and humans. Experimental gerontology, 70, 11-17. 
Kodama, Satoru, Tanaka, Shiro, Saito, Kazumi, Shu, Miao, Sone, Yasuko, Onitake, Fumiko, . . . Kondo, Kazuo. (2007). Effect of aerobic exercise training on serum levels of high-density lipoprotein cholesterol: a metaanalysis. Archives of internal medicine, 167(10), 999-1008. 
Löffler, Dennis, Müller, Ulrike, Scheuermann, Kathrin, Friebe, Daniela, Gesing, Julia, Bielitz, Julia, . . . Kiess, Wieland. (2015). Serum irisin levels are regulated by acute strenuous exercise. The Journal of Clinical Endocrinology & Metabolism, 100(4), 1289-1299. 
Ma, Chunlian, Ding, Haichao, Deng, Yuting, Liu, Hua, Xiong, Xiaoling, & Yang, Yi. (2021). Irisin: a new code uncover the relationship of skeletal muscle and cardiovascular health during exercise. Frontiers in physiology, 12, 620608. 
Miyamoto-Mikami, Eri, Sato, Koji, Kurihara, Toshiyuki, Hasegawa, Natsuki, Fujie, Shumpei, Fujita, Satoshi, . . . Iemitsu, Motoyuki. (2015). Endurance training-induced increase in circulating irisin levels is associated with reduction of abdominal visceral fat in middle-aged and older adults. PloS one, 10(3), e0120354. 
Norheim, Frode, Langleite, Torgrim Mikal, Hjorth, Marit, Holen, Torgeir, Kielland, Anders, Stadheim, Hans Kristian, . . . Drevon, Christian A. (2014). The effects of acute and chronic exercise on PGC‐1α, irisin and browning of subcutaneous adipose tissue in humans. The FEBS journal, 281(3), 739-749. 
Nygaard, Håvard, Slettaløkken, Gunnar, Vegge, Geir, Hollan, Ivana, Whist, Jon Elling, Strand, Tor, . . . Ellefsen, Stian. (2015). Irisin in blood increases transiently after single sessions of intense endurance exercise and heavy strength training. PloS one, 10(3), e0121367. 
Organization, World Health. (2002). The world health report 2002: reducing risks, promoting healthy life: World Health Organization.
Ortega, Francisco B, Sui, Xuemei, Lavie, Carl J, & Blair, Steven N. (2016). Body mass index, the most widely used but also widely criticized index: would a criterion standard measure of total body fat be a better predictor of cardiovascular disease mortality? Paper presented at the Mayo Clinic Proceedings.
Pedersen, Bente K, & Febbraio, Mark A. (2012). Muscles, exercise and obesity:
skeletal muscle as a secretory organ. Nature Reviews Endocrinology, 8(8), 457-465. 
Pekkala, Satu, Wiklund, Petri K, Hulmi, Juha J, Ahtiainen, Juha P, Horttanainen, Mia, Pöllänen, Eija, . . . Nyman, Kai. (2013). Are skeletal muscle FNDC5 gene expression and irisin release regulated by exercise and related to health? The Journal of physiology, 591(21), 5393-5400. 
Qian, Wanbin, Chen, Kaiqing, Yang, Jiayue, & BU, Ruifang. (2017). Association of plasma irisin level with prevalence of type 2 diabetes mellitus and physical activity. Chinese Journal of Endocrinology and Metabolism, 838-841. 
Ramezankhany, Azam, Nazar Ali, Parvaneh, & Hedayati, Mahdi. (2011). Comparing effects of aerobics, pilates exercises and low calorie diet on leptin levels and lipid profiles in sedentary women. Iranian Journal of Basic Medical Sciences, 14(3), 256-263. 
Son, Jun Seok, Chae, Song Ah, Testroet, Eric D, Du, Min, & Jun, Hyung-pil. (2018). Exercise-induced myokines: a brief review of controversial issues of this decade. Expert review of endocrinology & metabolism, 13(1), 5158. 
Tolson, Kristen P, Garcia, Christian, Delgado, Iris, Marooki, Nuha, & Kauffman, Alexander S. (2016). Metabolism and energy expenditure, but not feeding or glucose tolerance, are impaired in young Kiss1r KO female mice. Endocrinology, 157(11), 4192-4199. 
Yang, Dan, Yang, Yifan, Li, Yanlin, & Han, Rui. (2019). Physical exercise as therapy for type 2 diabetes mellitus: From mechanism to orientation. Annals of nutrition and metabolism, 74(4), 313-321. 
Yetgin, Meral Küçük, Agopyan, Ani, Küçükler, Ferit Kerim, Gedikbaşı, Asuman, Yetgin, Soner, Kayapınar, Fatma Çelik, . . . Çotuk, Hasan Birol. (2020).
 The Effects of Resistance and Aerobic Exercises on Adiponectin, Insulin Resistance, Lipid Profile and Body Composition in Adolescent Boys with Obesity. Istanbul Medical Journal, 21(3).