Document Type : Research Paper
Authors
1 Msc of Exercise Physiology, Department of Physical Education and sport science, Faculty of Psychology and Education Science, University of Mohaghegh Ardabili, Ardabil, Iran.
2 Professor of Exercise Physiology, Department of Physical Education and sport science, Faculty of Psychology and Education Science, University of Mohaghegh Ardabili, Ardabil, Iran.
3 Ph.D. student of Exercise Physiology, Department of Physical Education and Sport Sciences, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran.
Abstract
Purpose: The activity of plasma liver enzymes is intensified under the influence of sports activities, which is affected by the duration, intensity, type and method of training. The purpose of this study was to investigate the effect of a special endurance training session on the activity of serum alkaline phosphatase and aspartate aminotransferase liver enzymes in inactive young men.
Methods: In this semi-experimental study, 16 young inactive men were purposefully selected and examined in two groups (experimental and control). The experimental group performed Bruce's protocol after preliminary warm-up. Blood samples were collected before the test, immediately after the test, 24 hours and 48 hours after the test from both groups at the same time, and the amount of serum ALP (Alkaline Phosphatase) and AST (Aspartate Transaminase) enzymes were measured using an Auto analyzer. Statistical analysis of the data, independent T-test was used to compare the results of two groups and Bonferroni's post hoc test was used to determine the difference between different stages of sampling with a minimum significance level (P≥0.05).
Results: The results of the independent T-test in the comparison between the groups showed that there is a significant difference between the two groups in the amount of ALP enzyme in the time intervals immediately after the activity (P≥0.020), but in the time intervals of 24 (P≥0.177) and 48 hours (P≥0.136), there is no significant difference between the two groups after the activity. The results of the independent T test did not show any significant changes in the amount of AST enzyme in any of the time intervals in the comparison between groups.
Conclusion: Fatigue-inducing sports activity leads to an increase in the amount of enzymes, ALP, this increase can be a sign of damage to liver cells or heart muscle. Considering the role of recovery in liver damage, it seems that by considering enough rest time, it is possible to help improve the adaptation process while preventing the occurrence of muscle and liver damage
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Main Subjects
Rinonapoli G, R. C., Meccariello L, Bisaccia M, Ceccarini P, Caraffa A. Osteoporosis in Men: A Review of an Underestimated Bone Condition. International journal of molecular sciences. 2021;22(4):2105.,
Bouvard B, A. C., Legrand E. Osteoporosis in older adults. Joint Bone Spine.
2021;88(3):105135.,
Thambiah SC, Y. S. O. i. S.-E. A. C. T. c. b. r.,
Fahimfar N, N. S., Yousefi S, Gharibzadeh S, Shafiee G, Panahi N, et al. Prevalence of osteoporosis among the elderly population of Iran. Archives of Osteoporosis. 2021;16(1):1-10.,
BRAGONZONI L, B. G., PINELLI E, BENVENUTI F, DALLOLIO L, editors.
ACTLIFE PROTOCOL FOR OSTEOPOROTIC WOMEN:
PRELIMINARY RESULTS AT 6 MONTHS. BOOK OF ABSTRACTS.,
SHarMa H, a. K. B., naInCY PurWar SK, Saran S. Endocrine Causes of Secondary Osteoporosis in Adults: Mechanisms and Evaluation. Journal of Clinical & Diagnostic Research. 2021;15(1)
Prieto‐Alhambra D, P. M., Fina Avilés F, Hermosilla E, Martinez‐Laguna D, Carbonell‐Abella C, et al. The association between fracture and obesity is site‐dependent: a population‐based study in postmenopausal women. Journal of bone and mineral research. 2012;27(2):294-300.
Bashiri, J., Hadi, H., Bashiri, M., Nikbakht, H., & Gaeini, A. (2010). Effect of concurrent creatine monohydrate ingestion and resistance training on hepatic enzymes activity levels in non-athlete males. Iranian journal of endocrinology and metabolism, 12(1), 42-47.
Bergmann, C., Fliegauf, M., Brüchle, N. O., Frank, V., Olbrich, H., Kirschner, J., . . . Kränzlin, B. (2008). Loss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasia. The American Journal of Human Genetics, 82(4), 959-970.
Chamera, T., Spieszny, M., Klocek, T., Kostrzewa-Nowak, D., Nowak, R., Lachowicz, M., . . . Cieszczyk, P. (2014). Could biochemical liver profile help to assess metabolic response to aerobic effort in athletes? The Journal of Strength & Conditioning Research, 28(8), 2180-2186.
Chaudhary, A., gul Javaid, K., Bughio, E., & Faisal, N. (2023). Study on histobiochemical biomarkers of chromium induced toxicity in Labeo rohita. Emerging Contaminants, 100204.
Contrepois, K., Wu, S., Moneghetti, K. J., Hornburg, D., Ahadi, S., Tsai, M.-S., .
. . Quijada, J. V. (2020). Molecular choreography of acute exercise. Cell, 181(5), 1112-1130. e1116.
Elham, B., Somayeh, S., Afsaneh, S.-B., Azadeh, G., Mohammadreza, G., Saba, S., & Masoomeh, R. (2019). The effect of metformin in the treatment of intractable and late onset acne: a comparison with oral isotretinoin. Iranian Journal of Dermatology, 22(2), 47-52.
Ghalandari, K., Shabani, M., Khajehlandi, A., & Mohammadi, A. (2020). Effect of aerobic training with silymarin consumption on glycemic indices and liver enzymes in men with type 2 diabetes. Archives of Physiology and Biochemistry, 1-6.
Ghorbani, P., & Gaeini, A. (2013). The effect of one bout high intensity interval training on liver enzymes level in elite soccer players. J. Basic Appl. Sci, 5, 1191-1194.
Ghorbani, P., Kordi, M. R., Gaeeni, A. A., Arbab, G., & Nafar, M. H. (2013). Changes in inflammatory factors in elite soccer players folllowing single bout high intensity interval training. Brazilian Journal of Biomotricity, 7(1), 52-58.
Ghosh, A., Onsager, C., Mason, A., Arriola, L., Lee, W., & Mubayi, A. (2021). The role of oxygen intake and liver enzyme on the dynamics of damaged hepatocytes: Implications to ischaemic liver injury via a mathematical model. PloS one, 16(4), e0230833.
Huang, H., & Zhao, Y. (2022). Effect of clove on improving running ability in aging mice. Journal of Food Biochemistry, 46(10), e14339.
Kanda, K., Sugama, K., Sakuma, J., Kawakami, Y., & Suzuki, K. (2014). Evaluation of serum leaking enzymes and investigation into new biomarkers for exercise-induced muscle damage. Exercise immunology review, 20.
Keating, S. E., Hackett, D. A., George, J., & Johnson, N. A. (2012). Exercise and non-alcoholic fatty liver disease: a systematic review and meta-analysis. Journal of hepatology, 57(1), 157-166.
Mahdavi Asiabar, M., Nasiri Farsani, M., & Gheibi, N. (2021). Assessment of Propolis Supplementation on Serum Concentrations of Liver Enzymes in Endurance Athletes with Four Weeks Aerobic Training. Journal of Inflammatory Diseases, 25(1), 25-30.
Malakouti, M., Kataria, A., Ali, S. K., & Schenker, S. (2017). Elevated liver enzymes in asymptomatic patients–what should I do? Journal of clinical and translational hepatology, 5(4), 394.
Malandish, A., Tartibian, B., & Rahmati Yamchi, M. (2016). Effect of 12 Weeks of Moderate-Intensity Aerobic Training on Bone Density and Serum Indices of Bone in Sedentary Postmenopausal Women. Sport physiology, 8(32), 67-84.
McCarthy, A. D., Cortizo, A. M., & Sedlinsky, C. (2016). Metformin revisited: Does this regulator of AMP-activated protein kinase secondarily affect bone metabolism and prevent diabetic osteopathy. World journal of diabetes, 7(6), 122.
Mohammad, P., Esfandiar, K. Z., Abbas, S., & Ahoora, R. (2019). Effects of moderate-intensity continuous training and high-intensity interval training on serum levels of resistin, chemerin and liver enzymes in streptozotocin-nicotinamide induced type-2 diabetic rats. Journal of diabetes & metabolic disorders, 18, 379-387.
Nobahar, M., Mirdar Harijani, S., & Gorgin Karaji, Z. (2020). A survey of one and two inceremental exercise sessions per day during a week on time response of muscles and liver stress enzymes in active girls. Journal of Practical Studies of Biosciences in Sport, 8(15), 140-151.
Rezaei, M., & Namdar, S. (2013). The effects of three sessions of running on a negative slope on serum levels of liver enzymes in adult male rats. Zahedan Journal of Research in Medical Sciences, 15(5).
Sargazi, M., & Taghian, F. (2020). The Effect of Royal Jelly and Exercise on Liver Enzymes in Addicts. Archives of Pharmacy Practice, 11(2).
Shamsoddini, A., Sobhani, V., Chehreh, M. E. G., Alavian, S. M., & Zaree, A. (2015). Effect of aerobic and resistance exercise training on liver enzymes and hepatic fat in Iranian men with nonalcoholic fatty liver disease. Hepatitis monthly, 15(10).
Tartibian, B., Malandish, A., Afsargharehbagh, R., Eslami, R., & Sheikhlou, Z. (2018). Assessment of hepatic and lipid profiles following 12 weeks of aerobic exercise in overweight postmenopausal women. International Journal of Basic Science in Medicine, 3(4), 159-167.
van der Windt, D. J., Sud, V., Zhang, H., Tsung, A., & Huang, H. (2018). The effects of physical exercise on fatty liver disease. Gene expression, 18(2), 89.
Yasmin, A., Rukunuzzaman, M., Karim, A. B., Alam, R., Hossen, K., & Sonia, Z.
- (2022). Ratio of aspartate aminotransferase to alanine aminotransferase
and alkaline phosphatase to total bilirubin in Wilsonian acute liver failure in children. Indian Journal of Gastroenterology, 41(3), 224-230.
Sütken, E., Akalin, A., Özdemir, F., & Çolak, Ö. (2010). Lipid profile and levels of homocysteine, leptin, fibrinogen and C-reactive protein in hyperthyroid patients before and after treatment. Dicle Tıp Dergisi, 37(1), 1-7.
Taravati, T., Irandoust, K., & Rahimi, A. (2017). The effects of 8 weeks high intensity interval training (hiit) with garlic complement On some lipid profiles in obese inactive women. Acta medica mediterranea, 33, 271274.
Tofighi, A., Jamali, B., Babaei, S., & Amaghani, A. (2017). Effect of regular exercise on serum levels of homocysteine and lipid profile in obese female. Medical Journal of Tabriz University of Medical Sciences, 39(5), 20-27.
Wewege, M., Van Den Berg, R., Ward, R., & Keech, A. (2017). The effects of high‐intensity interval training vs. moderate‐intensity continuous training on body composition in overweight and obese adults: a systematic review and meta‐analysis. Obesity Reviews, 18(6), 635-646.
Wharton, C., & Nustad, J. K. (2006). Effects of the amount and intensity of exercise on plasma lipoproteins: Editor's comments. American Journal of Health Promotion, 20(4).
Yun, J., Kim, J. Y., Kim, O. Y., Jang, Y., Chae, J. S., Kwak, J. H., . . . Lee, J. H. (2011). Associations of plasma homocysteine level with brachial-ankle pulse wave velocity, LDL atherogenicity, and inflammation profile in healthy men. Nutrition, Metabolism and Cardiovascular Diseases, 21(2), 136-143.
Zhang, H., Tong, T. K., Qiu, W., Zhang, X., Zhou, S., Liu, Y., & He, Y. (2017). Comparable effects of high-intensity interval training and prolonged continuous exercise training on abdominal visceral fat reduction in obese young women. Journal of diabetes research, 2017.
Zmuda, J. M., Yurgalevitch, S. M., Flynn, M. M., Bausserman, L. L., Saratelli, A., Spannaus-Martin, D. J., . . . Thompson, P. D. (1998). Exercise training has little effect on HDL levels and metabolism in men with initially low HDL cholesterol. Atherosclerosis, 137(1), 215-221.
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