Objective: As the global population ages, chronic inflammation, particularly in overweight elderly individuals, plays a crucial role in the development of age-related diseases such as cardiovascular disease, diabetes, and metabolic syndrome. C-reactive protein (CRP) and adiponectin are key biomarkers that reflect inflammation and metabolic health. This study aimed to investigate the effect of eight weeks of aerobic training on serum levels of some inflammatory cytokines in overweight elderly men. Methods: A total of 20 overweight elderly men (aged 65-75) participated in the study. The experimental group (n=10) underwent eight weeks of aerobic training, while the control group (n=10) did not participate in any exercise program. CRP and adiponectin levels were measured before and after the intervention. Statistical analysis was performed using paired t-tests for within-group comparisons, and independent t-tests for between-group comparisons. Results: The experimental group showed significant reductions in CRP (from 5.8 mg/L ± 1.2 to 3.5 mg/L ± 0.9, p < 0.001) and increases in adiponectin (from 6.3 µg/mL ± 1.5 to 8.1 µg/mL ± 1.7, p < 0.001). The control group showed no significant changes in either CRP or adiponectin levels (p > 0.05). Conclusion: Eight weeks of aerobic training significantly reduced CRP levels and increased adiponectin in overweight elderly men. These findings suggest that aerobic exercise can be an effective intervention for reducing chronic inflammation and improving metabolic health in aging populations. Future studies should explore the long-term benefits and underlying mechanisms of exercise-induced changes in inflammatory markers.