Document Type : Research Paper
Authors
1 Department of Exercise Physiology, Faculty of Physical Education, Pardis Shomal University, Amol, Iran
2 Department of Exercise Physiology, Faculty of Humanities, Islamic Azad University, Hamedan Branch, Hamedan, Iran
Abstract
Purpose: Type 2 diabetes is a chronic metabolic disorder that, in addition to causing metabolic disturbances, has detrimental effects on the central nervous system, particularly the hippocampus. This study aimed to investigate the effects of endurance training on body weight changes, serum glucose levels, and NLRP-1 protein expression in the hippocampus of diabetic rats. Method: In this experimental study, 28 male Wistar rats, aged 10 weeks and weighing 245 grams, were divided into four groups: diabetic control, diabetic exercise, healthy control, and healthy exercise. Diabetes was induced by intraperitoneal injection of streptozotocin (STZ). The exercise groups underwent 6 weeks of endurance training on a treadmill, 5 sessions per week. Serum glucose levels, body weight, and NLRP-1 protein expression in the hippocampus were measured using standard techniques. Results: The results showed that endurance training significantly reduced serum glucose levels and stabilized body weight in the diabetic exercise group compared to the diabetic control group (p<0.05). Furthermore, NLRP-1 protein expression in the hippocampus was significantly decreased in the diabetic exercise group compared to the diabetic control group (p<0.05). Conclusion: These findings indicate that endurance training positively impacts glucose metabolism and reduces neuroinflammation in a diabetic rat model. The decrease in NLRP-1 expression in the hippocampus suggests that endurance exercise has anti-inflammatory and neuroprotective effects. Endurance training, as a non-pharmacological strategy, could improve the management of diabetes and prevent neural damage in diabetic individuals.
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