Objective:
Obesity and physical inactivity are associated with increased cardiovascular and thrombotic risk, partly through alterations in coagulation and endothelial function. Elevated fibrinogen and von Willebrand factor (vWF) are recognized markers of a prothrombotic state and endothelial activation in obese individuals. The present study aimed to investigate the effects of moderate-intensity continuous training (MICT) on fibrinogen and vWF levels in inactive obese women.
Methods:
This quasi-experimental study was conducted on 30 inactive obese women who were randomly assigned to an experimental (MICT, n=15) or control group (n=15). The experimental group participated in an 8-week MICT program, while the control group maintained their usual lifestyle. Anthropometric variables and fasting blood samples were collected before and after the intervention to assess plasma fibrinogen and vWF levels. Data were analyzed using paired- and independent-sample t tests.
Results:
After the intervention, the MICT group showed significant reductions in body weight (p = 0.004) and body mass index (p=0.006). Plasma fibrinogen levels significantly decreased in the MICT group (p=0.001), whereas no significant change was observed in the control group (p=0.62). Similarly, vWF levels were significantly reduced following MICT (p=0.002), with no significant change in the control group (p=0.54). Between-group comparisons at post-test revealed significantly lower fibrinogen (p=0.003) and vWF (p=0.005) levels in the MICT group compared with controls.
Conclusion:
These findings indicate that moderate-intensity continuous training is an effective and practical intervention for improving coagulation and endothelial biomarkers in inactive obese women and may contribute to reducing obesity-related cardiovascular risk.