New Approaches in Exercise Physiology

A Bibliometric Overview of Exerkines: Uncovering the Hidden Benefits of Exercise Training and Physical Activity

Document Type : Review Article

Authors

Hossein Poorhabibi 1
Beat Knechtle 2
Bakhtyar Tartibian 3
Rasoul Eslami 3
Mazaher Rahimpour 4

1 Department of Exercise Physiology, Faculty of Physical Education and Sports Sciences, Allameh Tabataba'i University, Tehran, Iran

2 Institute of Primary Care, University and University Hospital of Zurich, Zurich, Switzerland

3 Department of Exercise Physiology, Faculty of Physical Education and Sports Sciences, Allameh Tabataba'i University, Tehran, Iran

4 Islamic Azad University, Firoozkouh Branch, Tehran.Iran

https://doi.org/10.22054/nass.2026.92820.1233
Abstract
Background: Exerkines, bioactive molecules released during physical activity, are key mediators of exercise-related health benefits, including disease prevention, health promotion, and enhanced resilience. Despite their significance, no bibliometric analysis of exerkine research has been conducted. Method: This study aims to provide a comprehensive bibliometric overview of exerkine studies from 2016 to 2024, using the Web of Science database. We analyzed 131 publications through the Bibliometrix R package and VOSviewer to explore publication trends, key contributors, and research hotspots. Results: Results show a 55.39% annual growth rate, with 87 journals publishing in this field, led by Frontiers in Physiology. China and the USA contributed the most publications. High-frequency keywords included skeletal muscle, physical activity, and insulin resistance, reflecting core research areas. Ewa Ziemann was the most prolific author. Conclusion: This analysis highlights global research trends, influential journals, and emerging themes, offering a foundation for future investigations. By mapping the current state and potential directions of exerkine research, this study supports researchers in advancing knowledge and optimizing exercise-based interventions.
 

Keywords

bibliometric analysis
exercise training
physical activity
exerkines
Subjects
New Approaches in Exercise Physiology
Volume 8, Issue 16
December 2026
Pages 24-51

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